Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20275276 | 0.83 | SSTR4 (0.47) | SSTR4NR1H2PTPN2PTPN1PTPN6 | |
| SCHEMBL29663561 | 0.83 | NR1H2 (0.46) | KMT2ASSTR4NR1H2PTPN2PTPN1 | |
| SCHEMBL29215893 | 0.83 | NR1H2 (0.46) | KMT2ASSTR4NR1H2PTPN2PTPN1 | |
| SCHEMBL28934755 | 0.83 | NR1H2 (0.46) | KMT2ASSTR4NR1H2PTPN2PTPN1 | |
| SCHEMBL29215883 | 0.81 | SSTR4 (0.52) | SSTR4NR1H2PTPN2PTPN1PTPN6 | |
| SCHEMBL30241500 | 0.81 | SSTR4 (0.52) | SSTR4NR1H2PTPN2PTPN1PTPN6 | |
| SCHEMBL16182190 | 0.81 | SSTR4 (0.46) | SSTR4NR1H2PTPN2PTPN1PTPN6 | |
| SCHEMBL16182226 | 0.81 | NR1H2 (0.41) | KMT2ASSTR4NR1H2PTPN2PTPN1 | |
| SCHEMBL12835644 | 0.81 | NR1H2 (0.41) | KMT2ASSTR4NR1H2PTPN2PTPN1 | |
| SCHEMBL9965920 | 0.81 | NR1H2 (0.41) | KMT2ASSTR4NR1H2PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157432-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME, CORP. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157432-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | KMT2A 4265/4885SSTR4 462/4885NR1H2 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.