Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401564 | 0.88 | GRM5 (0.37) | CDK7 | |
| SCHEMBL9970820 | 0.88 | GRM5 (0.37) | CDK7 | |
| SCHEMBL9967249 | 0.83 | GSK3A (0.45) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9977728 | 0.81 | GSK3A (0.39) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL16199061 | 0.81 | GSK3A (0.39) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL15399800 | 0.81 | GSK3A (0.39) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9970823 | 0.78 | BTK (0.34) | CDK7 | |
| SCHEMBL21657500 | 0.78 | GSK3A (0.58) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9967094 | 0.77 | GSK3A (0.40) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL21657410 | 0.77 | GSK3A (0.56) | GSK3AGSK3BFLT3JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083122-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |