Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 10/20 | 0.34 |
| ▸ | HTT | P42858 | 6/20 | 0.34 |
| ▸ | MITF | O75030 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99873 | 0.74 | — | — | |
| SCHEMBL99611 | 0.73 | MAPT (0.36) | ALDH1A1GAAMAPTNPC1 | |
| SCHEMBL2186138 | 0.68 | ALDH1A1 (0.30) | ALDH1A1LMNA | |
| SCHEMBL100858 | 0.68 | — | — | |
| SCHEMBL21251037 | 0.67 | CDC7 (0.30) | — | |
| SCHEMBL15970561 | 0.65 | JAK2 (0.33) | — | |
| SCHEMBL31347135 | 0.65 | MAPT (0.42) | ALDH1A1MAPTLMNAPOLBKDM4E | |
| SCHEMBL2184103 | 0.64 | JAK2 (0.35) | — | |
| SCHEMBL15646250 | 0.63 | KDM4E (0.36) | LMNAKDM4ENUDT1 | |
| SCHEMBL5668816 | 0.62 | MAPT (0.43) | ALDH1A1MAPTMITFLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |