Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930585 | 0.88 | CCR2 (0.69) | CCR2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9968042 | 0.80 | CCR2 (0.48) | CCR2ALDH1A1MAPTTP53HPGD | |
| SCHEMBL7590525 | 0.74 | NPC1 (0.63) | CCR2ALDH1A1KMT2ATP53HPGD | |
| SCHEMBL9968200 | 0.73 | CCR2 (0.62) | CCR2MEN1KMT2AMAPTTP53 | |
| SCHEMBL16747597 | 0.71 | CCR2 (0.48) | CCR2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9930512 | 0.70 | CCR2 (1.00) | CCR2 | |
| SCHEMBL9968068 | 0.70 | CCR2 (0.64) | CCR2MEN1KMT2A | |
| SCHEMBL9968208 | 0.70 | PKM (0.56) | CCR2MEN1KMT2A | |
| SCHEMBL9930712 | 0.69 | CCR2 (0.73) | CCR2MEN1KMT2AMAPTLMNA | |
| SCHEMBL7592227 | 0.69 | CCR2 (0.67) | CCR2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082633-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | disclosed |