Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25609376 | 0.83 | CRHBP (0.37) | CYP11B1CYP11B2CRBNALDH1A1CRHBP | |
| SCHEMBL1753879 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CRBNCHRM2LRRK2 | |
| SCHEMBL16189944 | 0.80 | — | — | |
| SCHEMBL18806140 | 0.79 | CHRM2 (0.34) | CYP11B1CYP11B2GRIN2DGRIN3BCHRM2 | |
| SCHEMBL18806137 | 0.78 | CYP11B1 (0.33) | CYP11B1CYP11B2GRIN2DGRIN3BCHRM2 | |
| SCHEMBL12832226 | 0.76 | CYP11B1 (0.46) | CYP11B1CYP11B2CRBNCHRM2 | |
| SCHEMBL24186788 | 0.75 | CYP11B1 (0.46) | CYP11B1CYP11B2CRBNLRRK2 | |
| SCHEMBL17485296 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2CRBNCHRM2OPRM1 | |
| SCHEMBL12243268 | 0.75 | CYP11B1 (0.44) | CYP11B1CYP11B2CRBN | |
| SCHEMBL25990796 | 0.75 | GRIN2D (0.41) | GRIN2DGRIN3BCHRM2CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357242-A1 | COMPOUND AS AKT KINASE INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-11-09 | — | — | US | disclosed |
| US-20230357242-A1 | COMPOUND AS AKT KINASE INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-11-09 | — | — | US | disclosed |
| US-20200230117-A1 | NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2020-07-23 | — | — | US | disclosed |
| US-9056865-B2 | Pyridine-2-derivatives as smoothened receptor modulators | PFIZER INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | CYP11B1 1338/4885CYP11B2 1556/4885CRBN 395/4885 |
| US-20230357242-A1 | COMPOUND AS AKT KINASE INHIBITOR | AKT2, MTOR, AKT1 | CYP11B1 609/4885CYP11B2 668/4885CRBN 2602/4885 |
| US-20200230117-A1 | NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE | IDO1, IDO2, TDO2 | CYP11B1 455/4885CYP11B2 239/4885CRBN 3713/4885 |
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | SMO, EDNRB, RXFP1 | CYP11B1 1843/4885CYP11B2 1883/4885CRBN 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.