Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Tetraethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethylene Glycol SCHEMBL28909670 | 1.00 | MEN1 (0.58) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Tetrylammonium SCHEMBL28969143 | 0.97 | TSHR (0.56) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Tetrylammonium SCHEMBL8998036 | 0.95 | TSHR (0.59) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Triethylene Glycol SCHEMBL10416412 | 0.93 | MEN1 (0.50) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Water SCHEMBL10361743 | 0.88 | MEN1 (0.50) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Triethylene Glycol SCHEMBL9803037 | 0.87 | MEN1 (0.44) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL7648744 | 0.85 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9488670 | 0.83 | MEN1 (0.50) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Tetraethylene Glycol SCHEMBL14109914 | 0.80 | MEN1 (0.79) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Triethylene Glycol SCHEMBL10423729 | 0.80 | MEN1 (0.79) | MEN1KMT2ATSHRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8747799-B2 | Method of forming single-walled carbon nanotubes | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2014-06-10 | — | — | US | disclosed |
| US-20120171107-A1 | METHOD OF FORMING SINGLE-WALLED CARBON NANOTUBES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-07-05 | — | — | US | disclosed |
| WO-2011002417-A1 | METHOD OF FORMING SINGLE-WALLED CARBON NANOTUBES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2011-01-06 | — | — | WO | disclosed |