Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMD1 | P17707 | 3/20 | 0.50 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 6/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.42 |
| ▸ | DPY30 | Q9C005 | 1/20 | 0.42 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.42 |
| ▸ | AHCY | P23526 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955271 | 0.85 | ADORA3 (0.52) | DOT1LKMT2AAHCY | |
| SCHEMBL19711626 | 0.77 | ADORA1 (0.45) | AHCY | |
| SCHEMBL18314960 | 0.76 | POLB (0.49) | DOT1LKMT2AAHCY | |
| SCHEMBL22797505 | 0.75 | AMD1 (0.58) | AMD1EZH2DOT1LKMT2AAHCY | |
| SCHEMBL954272 | 0.75 | AMD1 (0.80) | AMD1EZH2DOT1LPRMT1CARM1 | |
| SCHEMBL954273 | 0.75 | AMD1 (0.80) | AMD1EZH2DOT1LPRMT1CARM1 | |
| SCHEMBL24601216 | 0.74 | TYMP (0.43) | DOT1LKMT2A | |
| SCHEMBL22143020 | 0.74 | ADA (0.53) | DOT1LKMT2A | |
| SCHEMBL19003202 | 0.74 | TYMP (0.43) | DOT1LKMT2A | |
| SCHEMBL18314959 | 0.74 | ADA (0.53) | DOT1LKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |