Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069013 | 0.89 | TLR8 (0.49) | KDM4EALDH1A1HPGDTLR8TRPV1 | |
| SCHEMBL4557233 | 0.87 | TLR8 (0.50) | TLR8TRPV1 | |
| SCHEMBL30336491 | 0.87 | TLR8 (0.50) | TLR8TRPV1 | |
| SCHEMBL27991341 | 0.86 | TLR8 (0.49) | TLR8TRPV1 | |
| SCHEMBL1514912 | 0.84 | CYP1A2 (0.42) | KDM4EALDH1A1GAAHPGDTLR8 | |
| SCHEMBL30838793 | 0.84 | CYP1A2 (0.42) | KDM4EALDH1A1GAAHPGDTLR8 | |
| SCHEMBL15796998 | 0.83 | ALDH1A1 (0.42) | KDM4EALDH1A1GAAHPGDLCK | |
| SCHEMBL5741619 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1HPGDCYP1A2HTR3A | |
| SCHEMBL30553021 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1HPGDCYP1A2HTR3A | |
| SCHEMBL6665065 | 0.81 | LOXL2 (0.41) | KDM4EALDH1A1HPGDTLR8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106831610-B | A kind of catalysis oxidation synthetic method of quinazoline compounds | 浙江工业大学 | 2019-03-19 | — | — | CN | disclosed |
| US-9725453-B2 | Imidazotriazinone compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| CN-106831610-A | A kind of catalysis oxidation synthetic method of quinazoline compounds | 浙江工业大学 | 2017-06-13 | — | — | CN | disclosed |
| US-20120157458-A1 | IMIDAZOTRIAZINONE COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. | 2012-06-21 | — | — | US | disclosed |
| EP-1954287-B1 | CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2011-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157458-A1 | IMIDAZOTRIAZINONE COMPOUNDS | PDE9A, PDE4A, PDE12 | KDM4E 1024/4885ALDH1A1 504/4885GAA 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.