Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101912 | 0.74 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL1102247 | 0.72 | POLB (0.66) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL14123302 | 0.66 | RXFP1 (0.59) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL1101900 | 0.64 | LMNA (0.77) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL19206540 | 0.60 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL5804877 | 0.60 | NPSR1 (0.65) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL9413995 | 0.59 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL19079782 | 0.59 | TSHR (0.73) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL3911841 | 0.59 | TP53 (0.68) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL1101914 | 0.59 | POLB (0.76) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |