Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | BRD4 | O60885 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284564 | 0.86 | KDM4E (0.59) | KDM4EBRD4ALDH1A1MAPK8MAPK10 | |
| SCHEMBL9617844 | 0.77 | KDM4E (0.67) | KDM4EBRD4ALDH1A1LMNAFSCN1 | |
| SCHEMBL15241737 | 0.75 | BRD4 (0.54) | KDM4EBRD4ALDH1A1LMNAMAPK10 | |
| SCHEMBL9974702 | 0.75 | MAPK10 (0.60) | KDM4EBRD4ALDH1A1MAPK8PDE10A | |
| SCHEMBL2430574 | 0.75 | NR4A2 (0.72) | KDM4EALDH1A1LMNANR4A2 | |
| SCHEMBL18584511 | 0.74 | ADRA1D (0.54) | KDM4EBRD4ALDH1A1MAPK8MAPK10 | |
| SCHEMBL1641959 | 0.73 | KDM4E (0.48) | KDM4EBRD4ALDH1A1LMNANR4A2 | |
| SCHEMBL2419642 | 0.73 | LMNA (0.52) | KDM4EBRD4LMNAFSCN1MAPK8 | |
| SCHEMBL8358799 | 0.72 | NR4A2 (0.53) | ALDH1A1LMNANR4A2 | |
| SCHEMBL28463880 | 0.72 | LMNA (0.73) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144881-B1 | ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |