Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974724 | 0.91 | HDAC8 (0.47) | LMNAPOLBALDH1A1HDAC8HDAC6 | |
| SCHEMBL12284336 | 0.91 | MAPK8 (0.43) | LMNAMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9974659 | 0.90 | P2RX7 (0.47) | LMNAPOLBALDH1A1ROCK2ROCK1 | |
| SCHEMBL9974663 | 0.88 | PTGS2 (0.45) | LMNAMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9974704 | 0.85 | MAPK14 (0.46) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2422151 | 0.84 | MAPK14 (0.51) | MAPK10 | |
| SCHEMBL2419000 | 0.82 | LMNA (0.39) | LMNAMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2417694 | 0.82 | LMNA (0.46) | LMNAPOLBHDAC8HDAC6HDAC11 | |
| SCHEMBL2419798 | 0.80 | GRIK1 (0.44) | LMNAMEN1KMT2AROCK2ROCK1 | |
| SCHEMBL2416357 | 0.80 | MEN1 (0.42) | LMNAMEN1KMT2AALDH1A1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144881-B1 | ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |