Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TK1 | P04183 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TK2 | O00142 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627311 | 1.00 | PIM1 (0.33) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL1624998 | 0.86 | LMNA (0.35) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL9975374 | 0.86 | LMNA (0.35) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL9975369 | 0.82 | TK1 (0.34) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL1626343 | 0.82 | TK1 (0.34) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL9975366 | 0.81 | HDAC6 (0.45) | ADORA3 | |
| SCHEMBL1627706 | 0.81 | HDAC6 (0.45) | ADORA3 | |
| SCHEMBL9975420 | 0.76 | LMNA (0.37) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL9975373 | 0.72 | LMNA (0.35) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL1626320 | 0.72 | LMNA (0.35) | PIM1CSNK2A2CSNK2BCSNK2A1CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270827-A1 | Indole Antiviral Compositions And Methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-25 | — | — | US | disclosed |
| US-8202844-B2 | Indole antiviral compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-06-19 | — | — | US | disclosed |
| US-20110178038-A1 | Indole Antiviral Compositions And Methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-21 | — | — | US | disclosed |
| US-7928080-B2 | Indole antiviral compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-04-19 | — | — | US | disclosed |
| US-7625871-B2 | Indole antiviral compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-12-01 | — | — | US | disclosed |
| US-20090281052-A1 | Indole Antiviral Compositions And Methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-11-12 | — | — | US | disclosed |
| US-7419963-B2 | Indole antiviral compositions and methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-09-02 | — | — | US | disclosed |
| US-20080146517-A1 | Indole Antiviral Compositions And Methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281052-A1 | Indole Antiviral Compositions And Methods | IDO1, IDO2, MAVS | PIM1 506/4885CSNK2A2 855/4885CSNK2B 829/4885 |
| US-20120270827-A1 | Indole Antiviral Compositions And Methods | IDO1, IDO2, MAVS | PIM1 506/4885CSNK2A2 855/4885CSNK2B 829/4885 |
| US-20080146517-A1 | Indole Antiviral Compositions And Methods | IDO1, IDO2, MAVS | PIM1 506/4885CSNK2A2 855/4885CSNK2B 829/4885 |
| US-20110178038-A1 | Indole Antiviral Compositions And Methods | IDO1, IDO2, MAVS | PIM1 506/4885CSNK2A2 855/4885CSNK2B 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.