Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121074 | 0.88 | ALOX5 (0.55) | ALOX5KDM4EGAAALDH1A1 | |
| SCHEMBL30530994 | 0.88 | ALOX5 (0.55) | ALOX5KDM4EGAAALDH1A1 | |
| SCHEMBL31191628 | 0.88 | ALOX5 (0.55) | ALOX5KDM4EGAAALDH1A1 | |
| SCHEMBL28571843 | 0.87 | ALOX5 (0.53) | ALOX5KDM4EGAAALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL31235549 | 0.87 | ALOX5 (0.53) | ALOX5KDM4EGAAALDH1A1HTR7 | |
| SCHEMBL3421834 | 0.81 | ALOX5 (0.50) | ALOX5ALDH1A1 | |
| Xanthene SCHEMBL4193453 | 0.79 | MAOA (0.49) | ALOX5MAPTKDM4EGAAMEN1 | |
| Phenoxazine SCHEMBL27618813 | 0.75 | ALOX5 (0.71) | ALOX5GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL27344796 | 0.73 | MAPT (0.52) | ALOX5MAPTKDM4EGAAMEN1 | |
| SCHEMBL2043484 | 0.72 | ALOX5 (0.53) | ALOX5MAPTKDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269996-B1 | MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE | HOSHI UNIVERSITY (JP) | 2012-10-17 | — | — | EP | disclosed |
| US-8288374-B2 | Medicinal composition containing benzo[a]phenoxazine compound as the active ingredient for prevention or treatment of protozoal disease | HOSHI UNIVERSITY (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20110021450-A1 | MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE | HOSHI UNIVERSITY (JP) | 2011-01-27 | — | — | US | disclosed |
| EP-2269996-A1 | MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE | Hoshi University (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021450-A1 | MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE | TBCA, THPO, PAOX | ALOX5 88/4885MAPT 1477/4885KDM4E 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.