Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999387 | 0.91 | KIF11 (0.36) | KIF11RXFP1SLC40A1ALDH1A1CYP2D6 | |
| SCHEMBL999103 | 0.88 | KIF11 (0.40) | KIF11RXFP1SLC40A1CYP2D6TNKS | |
| SCHEMBL998439 | 0.86 | KIF11 (0.37) | KIF11SLC40A1ALDH1A1CYP2D6TP53 | |
| SCHEMBL999207 | 0.82 | KIF11 (0.38) | KIF11RXFP1ALDH1A1CYP2D6 | |
| SCHEMBL997542 | 0.82 | KIF11 (0.38) | KIF11RXFP1SLC40A1ALDH1A1TDP1 | |
| SCHEMBL998181 | 0.81 | KIF11 (0.42) | KIF11RXFP1ALDH1A1TDP1TP53 | |
| SCHEMBL998701 | 0.80 | KIF11 (0.50) | KIF11TDP1TP53KDM4E | |
| SCHEMBL998800 | 0.80 | KIF11 (0.39) | KIF11RXFP1SLC40A1ALDH1A1CYP2D6 | |
| SCHEMBL1000704 | 0.79 | KIF11 (0.36) | KIF11RXFP1SLC40A1ALDH1A1CYP2D6 | |
| SCHEMBL996597 | 0.76 | KIF11 (0.39) | KIF11RXFP1SLC40A1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |