Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998702 | 0.90 | KIF11 (0.36) | KIF11RPS6KB1GRIN2BNPSR1ALDH1A1 | |
| SCHEMBL999103 | 0.87 | KIF11 (0.40) | KIF11RPS6KB1RXFP1MAPTESR1 | |
| SCHEMBL999384 | 0.86 | KIF11 (0.37) | KIF11RPS6KB1ALDH1A1TP53 | |
| SCHEMBL999207 | 0.85 | KIF11 (0.38) | KIF11RPS6KB1RXFP1AKT1ESR1 | |
| SCHEMBL998181 | 0.83 | KIF11 (0.42) | KIF11RXFP1MAPTESR1TDP1 | |
| SCHEMBL997628 | 0.82 | KIF11 (0.37) | KIF11RXFP1TDP1KDM4EALDH1A1 | |
| SCHEMBL998115 | 0.81 | KIF11 (0.52) | KIF11MAPTTDP1MEN1KMT2A | |
| SCHEMBL997834 | 0.79 | KIF11 (0.38) | KIF11RPS6KB1RXFP1MAPTAKT1 | |
| SCHEMBL998800 | 0.78 | KIF11 (0.39) | KIF11RPS6KB1RXFP1ESR1NPSR1 | |
| SCHEMBL998302 | 0.77 | KIF11 (0.37) | KIF11RPS6KB1AKT1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |