Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998567 | 0.90 | KIF11 (0.40) | KIF11MAPTESR1ACHEABCB1 | |
| SCHEMBL997862 | 0.86 | KIF11 (0.41) | KIF11MAPTESR1MAPK1KDM4E | |
| SCHEMBL999207 | 0.84 | KIF11 (0.38) | KIF11ESR1RXFP1MAPK1CDK9 | |
| SCHEMBL6007489 | 0.84 | KIF11 (0.39) | KIF11MAPTESR1ABCB1ABCG2 | |
| SCHEMBL999957 | 0.83 | KIF11 (0.38) | KIF11MAPTESR1ABCB1ABCG2 | |
| SCHEMBL997542 | 0.83 | KIF11 (0.38) | KIF11MAPTESR1RXFP1TDP1 | |
| SCHEMBL999103 | 0.82 | KIF11 (0.40) | KIF11MAPTESR1RXFP1TDP1 | |
| SCHEMBL998321 | 0.81 | KIF11 (0.61) | KIF11MAPTABCB1ABCG2TDP1 | |
| SCHEMBL997628 | 0.81 | KIF11 (0.37) | KIF11RXFP1TDP1KDM4EALDH1A1 | |
| SCHEMBL998662 | 0.79 | KIF11 (0.39) | KIF11MAPTESR1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |