Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | CA3 | P07451 | 4/20 | 0.33 |
| ▸ | CA4 | P22748 | 4/20 | 0.33 |
| ▸ | CA6 | P23280 | 4/20 | 0.33 |
| ▸ | CA5A | P35218 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12302214 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL17399559 | 0.89 | MEN1 (0.35) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL9976336 | 0.88 | MAPT (0.33) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL16093539 | 0.87 | CA12 (0.39) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL13234516 | 0.87 | MAOB (0.41) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL17399555 | 0.85 | PDK2 (0.35) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL21648614 | 0.83 | CASP3 (0.35) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL15942835 | 0.83 | TSHR (0.41) | SMN1; SMN2MEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL21896322 | 0.83 | MEN1 (0.31) | SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL17399556 | 0.83 | PDK2 (0.37) | SMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357569-A1 | CYCLOSPORIN CONJUGATES | UCL BUSINESS PLC (GB) | 2014-12-04 | — | — | US | disclosed |
| US-20120157385-A1 | CYCLOSPORIN CONJUGATES | UCL BUSINESS PLC (GB) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157385-A1 | CYCLOSPORIN CONJUGATES | CYP11B1, SHMT2, MRM1 | SMN1; SMN2 2310/4885MEN1 1425/4885KMT2A 3065/4885 |
| US-20140357569-A1 | CYCLOSPORIN CONJUGATES | CYP11B1, SHMT2, MRM1 | SMN1; SMN2 2225/4885MEN1 1363/4885KMT2A 3078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.