Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977538 | 0.93 | POLB (0.51) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL4606687 | 0.86 | LMNA (0.46) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL4595576 | 0.80 | MAOB (0.47) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL4595797 | 0.79 | TRPV1 (0.54) | — | |
| SCHEMBL4923161 | 0.79 | HDAC6 (0.40) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL10278887 | 0.78 | MAOB (0.46) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL4594671 | 0.78 | KMT2A (0.47) | KMT2AMEN1POLBLMNACYP2D6 | |
| SCHEMBL338386 | 0.76 | BCHE (0.52) | LMNAKCNH2 | |
| SCHEMBL3554203 | 0.76 | RAB9A (0.58) | KMT2AMEN1ALDH1A1HDAC6RAB9A | |
| SCHEMBL4872875 | 0.76 | MAPT (0.51) | KMT2AMEN1ALDH1A1LMNAMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874733-B1 | SUBSTITUTED CYCLIC UREA DERIVATIVES AND THE USE THEREOF AS VANILLOID RECEPTOR 1 MODULATORS | GRUENENTHAL GMBH (DE) | 2012-06-20 | — | — | EP | disclosed |