Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30737880 | 1.00 | AKT1 (0.48) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL29689263 | 0.82 | AKT2 (0.54) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL104535 | 0.79 | AKT2 (0.61) | AKT1AKT2ROCK2PDPK1 | |
| SCHEMBL30582723 | 0.77 | AKT2 (0.48) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL15327018 | 0.77 | AKT1 (0.48) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL26131947 | 0.77 | AKT2 (0.48) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL14896650 | 0.77 | CHEK1 (0.52) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL16131991 | 0.77 | CCR1 (0.56) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL3255522 | 0.77 | NPBWR1 (0.48) | AKT1AKT2MAPK1PIM1CHEK1 | |
| SCHEMBL29638874 | 0.75 | AKT2 (0.56) | AKT1AKT2MAPK1PIM1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862860-B1 | 1,3-OXAZOLIDINE OR 1,3-OXAZINANE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-12-21 | — | — | EP | disclosed |
| US-9266870-B2 | Heteroaromatic methyl cyclic amine derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-02-23 | — | — | US | disclosed |
| US-9266870-B2 | Heteroaromatic methyl cyclic amine derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-02-23 | — | — | US | disclosed |
| US-9266870-B2 | Heteroaromatic methyl cyclic amine derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-02-23 | — | — | US | disclosed |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-02 | — | — | US | disclosed |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-02 | — | — | US | disclosed |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-02 | — | — | US | disclosed |
| US-20150166523-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-06-18 | — | — | US | disclosed |
| US-20150166523-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-06-18 | — | — | US | disclosed |
| US-20150166523-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-06-18 | — | — | US | disclosed |
| EP-2862855-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2015-04-22 | — | — | EP | disclosed |
| EP-2862860-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013187466-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | 大正製薬株式会社 (JP) | 2013-12-19 | — | — | WO | disclosed |
| US-20130281465-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-24 | — | — | US | disclosed |
| US-20130281465-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-24 | — | — | US | disclosed |
| US-20130281465-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-24 | — | — | US | disclosed |
| EP-2653469-A1 | PYRAZOLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012081692-A1 | PYRAZOLE DERIVATIVE | 大正製薬株式会社 (JP) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166523-A1 | BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE | HCRTR2, HCRTR1, HTR2B | AKT1 2252/4885AKT2 2451/4885MAPK1 1524/4885 |
| US-20130281465-A1 | PYRAZOLE DERIVATIVE | HCRTR1, HCRTR2, NPY4R | AKT1 2563/4885AKT2 2764/4885MAPK1 1104/4885 |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | HCRTR2, HCRTR1, HTR2B | AKT1 1123/4885AKT2 1430/4885MAPK1 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.