Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL18297990 | 1.00 | SLC7A5 (0.52) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL29089914 | 0.95 | SLC7A5 (0.47) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL9978767 | 0.94 | SLC7A5 (0.46) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Phenylalanine SCHEMBL18297982 | 0.91 | SLC7A5 (0.50) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL27692833 | 0.90 | SLC7A5 (0.42) | SLC7A5ITGB3ITGA2BTHRBLNPEP | |
| Histidine SCHEMBL305856 | 0.90 | GSR (0.54) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| D-Histidine SCHEMBL902054 | 0.90 | GSR (0.54) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Histidine SCHEMBL16714200 | 0.90 | GSR (0.54) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Histidine SCHEMBL4297918 | 0.90 | GSR (0.54) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Histidine SCHEMBL4294462 | 0.90 | GSR (0.54) | SLC7A5ITGB3ITGA2BGSRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210275582-A1 | COMPOSITION OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE | 2021-09-09 | — | — | US | claimed |
| US-11058719-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | MOREHOUSE SCHOOL OF MEDICINE (US) | 2021-07-13 | — | — | US | claimed |
| US-9375451-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | NUTRIGLOBAL, INC. (US) | 2016-06-28 | — | — | US | claimed |
| US-20160058819-A1 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE | 2016-03-03 | — | — | US | claimed |
| US-8840950-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | MOREHOUSE SCHOOL OF MEDICINE | 2014-09-23 | — | — | US | claimed |
| EP-2575502-A2 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | Hibbert, Jacqueline M. (US) | 2013-04-10 | — | — | EP | claimed |
| US-20110294727-A1 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE (US) | 2011-12-01 | — | — | US | claimed |
| WO-2011149713-A2 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE (US) | 2011-12-01 | — | — | WO | claimed |
| US-20210275582-A1 | COMPOSITION OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE | 2021-09-09 | — | — | US | disclosed |
| US-11058719-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | MOREHOUSE SCHOOL OF MEDICINE (US) | 2021-07-13 | — | — | US | disclosed |
| US-9375451-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | NUTRIGLOBAL, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20160058819-A1 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE | 2016-03-03 | — | — | US | disclosed |
| US-8840950-B2 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore | MOREHOUSE SCHOOL OF MEDICINE | 2014-09-23 | — | — | US | disclosed |
| EP-2575502-A2 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | Hibbert, Jacqueline M. (US) | 2013-04-10 | — | — | EP | disclosed |
| US-20110294727-A1 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE (US) | 2011-12-01 | — | — | US | disclosed |
| WO-2011149713-A2 | COMPOSITIONS OF NUTRITION SUPPLEMENTATION FOR NUTRITIONAL DEFICIENCIES AND METHOD OF USE THEREFORE | MOREHOUSE SCHOOL OF MEDICINE (US) | 2011-12-01 | — | — | WO | disclosed |
| US-4376766-A | Anti-sickling agents | G.D. SEARLE & CO. (US) | 1983-03-15 | — | — | US | disclosed |
| US-4376766-A | Anti-sickling agents | G.D. SEARLE & CO. (US) | 1983-03-15 | — | — | US | disclosed |