Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PGD | P52209 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826506 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL10266772 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL675867 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL2749036 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL18219200 | 0.91 | ALDH1A1 (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL2526095 | 0.91 | MAPT (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL17885970 | 0.91 | ALDH1A1 (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL527434 | 0.91 | MAPT (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL17885973 | 0.91 | ALDH1A1 (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 | |
| SCHEMBL13587126 | 0.91 | MAPT (0.42) | ALDH1A1MAPTITGA4MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957056-B2 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTIUTE FOR CANCER RESEARCH (US) | 2015-02-17 | — | — | US | disclosed |
| US-20130256595-A1 | LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL ELEMENT, AND LIQUID CRYSTAL DISPLAY DEVICE | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2013-10-03 | — | — | US | disclosed |
| US-20130256595-A1 | LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL ELEMENT, AND LIQUID CRYSTAL DISPLAY DEVICE | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2013-10-03 | — | — | US | disclosed |
| US-8324284-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-12-04 | — | — | US | disclosed |
| US-8202911-B2 | Migrastatin analog compositions and uses thereof | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-20110263653-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-10-27 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| US-20070037783-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037783-A1 | Migrastatin analogs and uses thereof | FOXM1, MTX1, C3AR1 | ALDH1A1 1571/4885MAPT 3338/4885ITGA4 729/4885 |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | MTX1, MTNR1B, MTNR1A | ALDH1A1 2348/4885MAPT 4422/4885ITGA4 1004/4885 |
| US-20110263653-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | C3AR1, C1R, MRPS18A | ALDH1A1 1845/4885MAPT 3280/4885ITGA4 842/4885 |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | KDR, MTX1, FOXM1 | ALDH1A1 1124/4885MAPT 3143/4885ITGA4 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.