SCHEMBL9979922

SCHEMBL9979922

FOc1ccc(F)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 1/20 0.44
MAOB P27338 2/20 0.40
AOC3 Q16853 1/20 0.40
HTR2A P28223 1/20 0.38
SLC6A4 P31645 1/20 0.38
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
TRPA1 O75762 1/20 0.36
MAOA P21397 1/20 0.34
MAP4K4 O95819 1/20 0.34
NFE2L2 Q16236 2/20 0.32
SLC1A3 P43003 1/20 0.32
SLC1A2 P43004 1/20 0.32
SLC1A1 P43005 1/20 0.32
ESR1 P03372 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP1A1 P04798 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9979977 0.77 MRGPRX4 (0.41) SLC6A4ALDH1A1MAPTL3MBTL1CYP1A1
SCHEMBL1547827 0.76 SOS1 (0.42) SOS1MAOBAOC3HTR2ASLC6A4
SCHEMBL8228103 0.76 SOS1 (0.47) SOS1MAOBAOC3HTR2ASLC6A4
SCHEMBL21923071 0.76 SOS1 (0.42) SOS1MAOBAOC3HTR2ASLC6A4
SCHEMBL29513208 0.76 CA12 (0.50) SLC6A4NFE2L2ALDH1A1MAPTHTT
SCHEMBL254529 0.76 CA12 (0.50) SLC6A4NFE2L2ALDH1A1MAPTHTT
SCHEMBL7168416 0.76 SOS1 (0.42) SOS1MAOBAOC3HTR2ASLC6A4
SCHEMBL15088450 0.76 SOS1 (0.42) SOS1MAOBAOC3HTR2ASLC6A4
SCHEMBL177743 0.74 SOS1 (0.41) SOS1MAOBAOC3HTR2ASLC6A4
Hydrochloric Acid SCHEMBL12979488 0.74 SOS1 (0.46) SOS1MAOBAOC3HTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11795398-B2 Liquid-crystalline medium and liquid-crystal display comprising the same and compounds MERCK PATENT GMBH (DE) 2023-10-24 US disclosed
US-11788009-B2 Liquid-crystalline medium for use in a switching element MERCK PATENT GMBH (DE) 2023-10-17 US disclosed
US-11760931-B2 Liquid-crystalline medium for use in a switching element MERCK PATENT GMBH (DE) 2023-09-19 US disclosed
US-11739266-B2 Polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2023-08-29 US disclosed
US-11718791-B2 Polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2023-08-08 US disclosed
US-11702597-B2 Azo dye MERCK PATENT GMBH (DE) 2023-07-18 US disclosed
US-11667841-B2 Dibenzofuran and dibenzothiophene derivatives MERCK PATENT GMBH (DE) 2023-06-06 US disclosed
US-11667845-B2 Liquid crystalline medium MERCK PATENT GMBH (DE) 2023-06-06 US disclosed
US-20180195002-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-07-12 US disclosed
US-20180187080-A1 LIQUID CRYSTAL MEDIUM CONTAINING POLYMERISABLE COMPOUNDS MERCK PATENT GMBH (DE) 2018-07-05 US disclosed
US-7531106-B2 Mesogenic compounds, medium for electro-optical displays and electro-optical display MERCK PATENT GMBH (DE) 2009-05-12 US disclosed
US-7482044-B2 Liquid crystalline medium and liquid crystal display MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2009-01-27 US disclosed
US-7445819-B2 Liquid crystalline medium and liquid crystal display MERCK PATENT GMBH (DE) 2008-11-04 US disclosed
US-7442419-B2 Comprising one or more dielectrically positive compounds having a dielectric anisotropy of more than 3; twisted Nematic (TN) or Plane Switching (IPS) type; low rotational viscosity; polycyclo cyclohexyl fluorocarbon benzyl ether derivatives, electrooptics MERCK PATENT GMBH (DE) 2008-10-28 US disclosed
US-7438956-B2 Liquid-crystalline medium and liquid-crystal display MERCK PATENT GMBH (DE) 2008-10-21 US disclosed
US-20080149890-A1 Liquid Crystal Composition ADEKA CORPORATION (JP) 2008-06-26 US disclosed
US-20080124492-A1 Liquid crystalline medium and liquid crystal display MERCK PATENT GMBH 2008-05-29 US disclosed
US-20070235688-A1 Liquid crystalline medium and liquid crystal display MERCK PATENT GESELLSCHAFT 2007-10-11 US disclosed
US-20070228327-A1 LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2007-10-04 US disclosed
US-20070176146-A1 Liquid-crystalline medium and liquid-crystal display MERCK PATENT GMBH (DE) 2007-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11718791-B2 Polymerisable compounds and the use thereof in liquid-crystal displays VCL, ILK, LCP1 SOS1 1054/4885MAOB 3044/4885AOC3 3439/4885
US-11667845-B2 Liquid crystalline medium NEFM, CCNI, MYT1 SOS1 1183/4885MAOB 327/4885AOC3 1248/4885
US-11667841-B2 Dibenzofuran and dibenzothiophene derivatives DDT, MYT1, DBF4 SOS1 1360/4885MAOB 863/4885AOC3 2593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.