SCHEMBL9980065

SCHEMBL9980065

O=C(c1cccc(Nc2c(Nc3cccc(F)c3Cl)c(=O)c2=O)c1O)N1CCC2(CCNC2=O)CC1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 18/20 0.47
CXCR1 P25024 5/20 0.43
CCR6 P51684 1/20 0.41
SPR P35270 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30515699 1.00 CXCR2 (0.47) CXCR2CXCR1CCR6SPR
SCHEMBL9980053 0.88 CD274 (0.41) CXCR2CCR6SPR
SCHEMBL9980036 0.87 CXCR2 (0.52) CXCR2
SCHEMBL9979984 0.78 CXCR2 (0.74) CXCR2CXCR1
SCHEMBL9980086 0.78 CXCR2 (0.74) CXCR2CXCR1
SCHEMBL9979957 0.78 MAPK14 (0.48) CXCR2SPR
SCHEMBL9980014 0.78 CXCR2 (0.48) CXCR2CXCR1CCR6
SCHEMBL20452589 0.76 CXCR2 (0.63) CXCR2CXCR1CCR6
SCHEMBL9979970 0.76 CXCR2 (0.63) CXCR2CXCR1CCR6
SCHEMBL9979971 0.74 CXCR2 (0.65) CXCR2CXCR1CCR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-10660909-B2 Method for treating cancer using chemokine antagonists SYNTRIX BIOSYSTEMS INC. (US) 2020-05-26 US disclosed
WO-2019055509-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. (US) 2019-03-21 WO disclosed
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-23 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
WO-2017156270-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. (US) 2017-09-14 WO disclosed
EP-2651891-B1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INT (DE) 2016-07-13 EP disclosed
US-8648118-B2 Bicyclic ring system substituted amide functionalised phenols as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-11 US disclosed
US-8648118-B2 Bicyclic ring system substituted amide functionalised phenols as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-11 US disclosed
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-27 US disclosed
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-27 US disclosed
WO-2012080456-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885CXCR1 1/4885CCR6 20/4885
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885CXCR1 1/4885CCR6 20/4885
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders CXCR1, CXCR2, CXCR6 CXCR2 2/4885CXCR1 1/4885CCR6 20/4885
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF CXCR1, CXCR2, FPR2 CXCR2 2/4885CXCR1 1/4885CCR6 30/4885
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS CXCR1, CXCR2, CXCR5 CXCR2 2/4885CXCR1 1/4885CCR6 19/4885
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS CXCR2, CCR2, CCR1 CXCR2 1/4885CXCR1 5/4885CCR6 54/4885
US-10660909-B2 Method for treating cancer using chemokine antagonists CXCR1, CXCR2, CXCR5 CXCR2 2/4885CXCR1 1/4885CCR6 19/4885
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885CXCR1 1/4885CCR6 20/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.