Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.69 |
| ▸ | LMNA | P02545 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066385 | 0.87 | MAPT (0.72) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9980392 | 0.84 | MEN1 (0.51) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12065803 | 0.82 | MAPT (0.68) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9980456 | 0.78 | MAPT (0.77) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL23850443 | 0.78 | LMNA (0.71) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12067935 | 0.77 | MAPT (0.67) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12067991 | 0.77 | MAPT (0.66) | MAPTLMNAALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL9980398 | 0.75 | MAPT (0.60) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12067909 | 0.75 | MAPT (0.70) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1804544 | 0.75 | MAPT (0.79) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |