Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980419 | 0.86 | MEN1 (0.52) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL9980389 | 0.84 | MAPT (0.69) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL12065802 | 0.81 | MEN1 (0.45) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL9980390 | 0.80 | RAB9A (0.65) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL9980429 | 0.77 | GAA (0.54) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL12067920 | 0.77 | MEN1 (0.49) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL12065564 | 0.76 | MEN1 (0.49) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL12067173 | 0.75 | TNNI3K (0.56) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL9980388 | 0.75 | TNNI3K (0.56) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL23851443 | 0.74 | KDM4E (0.51) | MEN1KMT2ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |