Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.77 |
| ▸ | LMNA | P02545 | 6/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067909 | 0.88 | MAPT (0.70) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12066385 | 0.87 | MAPT (0.72) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1804544 | 0.86 | MAPT (0.79) | MAPTLMNAALDH1A1SMN1; SMN2PKM | |
| SCHEMBL23850890 | 0.86 | MAPT (0.58) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12067935 | 0.84 | MAPT (0.67) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12065803 | 0.82 | MAPT (0.68) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12067920 | 0.81 | MEN1 (0.49) | MAPTLMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12065779 | 0.80 | LMNA (0.69) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9980389 | 0.78 | MAPT (0.69) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12067991 | 0.78 | MAPT (0.66) | MAPTLMNACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |