Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 14/20 | 0.40 |
| ▸ | BRAF | P15056 | 6/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980396 | 0.87 | TNNI3K (0.44) | TNNI3KBRAFEGFR | |
| SCHEMBL12067916 | 0.74 | TNNI3K (0.62) | TNNI3KBRAF | |
| SCHEMBL12067874 | 0.72 | TNNI3K (0.63) | TNNI3KBRAF | |
| SCHEMBL9980375 | 0.71 | TNNI3K (0.40) | TNNI3KBRAFCA1CA2 | |
| SCHEMBL9986097 | 0.71 | TNNI3K (0.73) | TNNI3KBRAF | |
| SCHEMBL12067929 | 0.71 | TNNI3K (0.57) | TNNI3KBRAF | |
| SCHEMBL12065804 | 0.71 | TNNI3K (0.57) | TNNI3KBRAF | |
| SCHEMBL12065794 | 0.69 | TNNI3K (0.50) | TNNI3KBRAFMKNK1 | |
| SCHEMBL12065559 | 0.69 | TNNI3K (0.50) | TNNI3KBRAF | |
| SCHEMBL9980436 | 0.68 | TNNI3K (0.37) | TNNI3KBRAFCA1CA2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |