Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA3 | P07451 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA6 | P23280 | 2/20 | 0.47 |
| ▸ | CA5A | P35218 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219444 | 0.85 | LMNA (0.59) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL10154281 | 0.82 | LMNA (0.71) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL1503408 | 0.79 | MAPT (0.57) | LMNASMN1; SMN2GAACA1CA2 | |
| SCHEMBL11122473 | 0.79 | MAPT (0.57) | LMNASMN1; SMN2GAACA1CA2 | |
| SCHEMBL1808661 | 0.79 | VCAM1 (0.58) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL6933412 | 0.79 | GAA (0.63) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL1804387 | 0.79 | CA1 (0.50) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL17938382 | 0.79 | LMNA (0.49) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL1808891 | 0.78 | LMNA (0.51) | LMNASMN1; SMN2GAAL3MBTL1CA1 | |
| SCHEMBL1368132 | 0.78 | G6PD (0.55) | LMNASMN1; SMN2GAAL3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |