Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980400 | 0.92 | MAPT (0.63) | MAPTLMNAVCAM1ALDH1A1KDM4E | |
| SCHEMBL9978263 | 0.88 | MAPT (0.58) | MAPTLMNAVCAM1ALDH1A1KDM4E | |
| SCHEMBL9980398 | 0.86 | MAPT (0.60) | MAPTLMNAVCAM1ALDH1A1KDM4E | |
| SCHEMBL12065552 | 0.84 | MAPT (0.44) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL31022863 | 0.80 | LMNA (0.46) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12067991 | 0.79 | MAPT (0.66) | MAPTLMNAVCAM1ALDH1A1KDM4E | |
| SCHEMBL29512840 | 0.78 | KMT2A (0.46) | LMNAALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL12067109 | 0.76 | LMNA (0.61) | MAPTLMNAVCAM1ALDH1A1KDM4E | |
| SCHEMBL12067050 | 0.75 | MAPT (0.46) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9980456 | 0.72 | MAPT (0.77) | MAPTLMNAVCAM1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |