Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 13/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432507 | 0.77 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL9980693 | 0.77 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL3805125 | 0.77 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL9980933 | 0.76 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL9980718 | 0.76 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL3788649 | 0.74 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL18532674 | 0.70 | TLR7 (0.77) | TLR8TLR7 | |
| SCHEMBL25092903 | 0.66 | EPHX2 (0.50) | ALDH1A1TLR8TLR7EPHX2 | |
| SCHEMBL23805538 | 0.66 | EPHX2 (0.50) | ALDH1A1TLR8TLR7EPHX2 | |
| SCHEMBL26080263 | 0.65 | TLR7 (0.79) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179919-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2014-06-26 | — | — | US | disclosed |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | UNIV EMORY (US) | 2013-10-31 | — | — | US | disclosed |
| US-8551996-B2 | Compounds, compositions, methods of synthesis, and methods of treatment | EMORY UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179919-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | ALDH1A1 2345/4885TLR8 2356/4885TLR7 1583/4885 |
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | ALDH1A1 2772/4885TLR8 1902/4885TLR7 1015/4885 |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | ALDH1A1 2345/4885TLR8 2356/4885TLR7 1583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.