Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3887454 | 0.90 | ALDH1A1 (0.57) | ALDH1A1LTA4HSLC18A3SIGMAR1BCHE | |
| SCHEMBL1427979 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL4592570 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL1955800 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL4592170 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL16121539 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL1427977 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL8251471 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL20160542 | 0.84 | ALDH1A1 (0.71) | ALDH1A1HTTLTA4HTSHRKDM4E | |
| SCHEMBL1552926 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HTTLTA4HTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658131-B2 | Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2014-02-25 | — | — | US | disclosed |
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | SIGMAR1, TMEM97, OPRM1 | ALDH1A1 1548/4885HTT 1224/4885LTA4H 2341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.