Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978875 | 0.74 | HCAR2 (0.35) | PDE10A | |
| SCHEMBL992381 | 0.73 | P2RX7 (0.31) | — | |
| SCHEMBL980672 | 0.68 | PTGIR (0.35) | MAPTSMN1; SMN2 | |
| SCHEMBL986289 | 0.65 | HDAC6 (0.43) | MAPTLMNAHSD17B10GAAHPGD | |
| SCHEMBL979099 | 0.64 | NPSR1 (0.35) | MAPTLMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL1905179 | 0.64 | PIM1 (0.49) | MAPTMAPK1GAASMN1; SMN2 | |
| SCHEMBL15153028 | 0.63 | HCAR2 (0.32) | — | |
| SCHEMBL998166 | 0.62 | PDE10A (0.36) | PDE10ASMARCA2SMARCA4PBRM1LRRK2 | |
| SCHEMBL15405753 | 0.62 | KCNMA1 (0.44) | ROCK1CDC42BPBROCK2PDE10ASMARCA2 | |
| SCHEMBL977783 | 0.60 | S1PR3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |