Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30592258 | 0.69 | PIM1 (0.41) | PIM1PIM3PIM2KDM4E | |
| SCHEMBL29861473 | 0.65 | SOS1 (0.47) | HRH3 | |
| SCHEMBL3761998 | 0.64 | KDM4E (0.62) | KDM4E | |
| SCHEMBL30095774 | 0.64 | KDM4E (0.62) | KDM4E | |
| SCHEMBL9982816 | 0.64 | KDM4E (0.49) | KDM4E | |
| SCHEMBL9982976 | 0.64 | MEN1 (0.34) | PIM1PIM3PIM2KDM4E | |
| SCHEMBL4185095 | 0.63 | ALDH1A1 (0.41) | — | |
| SCHEMBL30812587 | 0.63 | KDM4E (0.34) | KDM4E | |
| SCHEMBL594726 | 0.62 | MEN1 (0.45) | KDM4E | |
| SCHEMBL10447432 | 0.62 | RAB9A (0.49) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |