Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 3/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525906 | 0.79 | KCNH2 (0.48) | HTR2CNPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL2526690 | 0.76 | MEN1 (0.41) | NPC1GAARAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL1813226 | 0.72 | KCNH2 (0.46) | NPC1GAARAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL31185337 | 0.72 | KCNH2 (0.46) | NPC1GAARAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL28648250 | 0.67 | CTRB1 (0.48) | P2RX4P2RX1P2RX3HTR2CCTRB1 | |
| SCHEMBL18251771 | 0.65 | GRM5 (0.42) | HTR2CTACR1 | |
| SCHEMBL7711512 | 0.64 | ENPP2 (0.54) | HTR2CNPC1GAAMAPK1RAB9A | |
| SCHEMBL30484110 | 0.63 | MEN1 (0.57) | NPC1MAPK1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27193593 | 0.63 | HTR2C (0.48) | HTR2CNPC1GAAMAPK1RAB9A | |
| SCHEMBL21800290 | 0.63 | ABHD6 (0.55) | HTR2CNPC1RAB9ASMN1; SMN2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861399-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-12-14 | — | — | EP | disclosed |