Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.54 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12020272 | 0.97 | ACHE (0.56) | ACHEAPOBEC3AAPOBEC3GALDH1A1MAPK1 | |
| SCHEMBL9013920 | 0.97 | ACHE (0.56) | ACHEAPOBEC3AAPOBEC3GALDH1A1MAPK1 | |
| SCHEMBL26628889 | 0.81 | ACHE (0.67) | ACHEAPOBEC3AAPOBEC3GTSHRLMNA | |
| M-Xylene SCHEMBL28287184 | 0.75 | ACHE (0.80) | ACHEALDH1A1MAPK1TSHRLMNA | |
| SCHEMBL13854404 | 0.75 | ACHE (0.62) | ACHEALDH1A1MAPK1TSHRTP53 | |
| M-Xylene SCHEMBL27645721 | 0.74 | — | — | |
| M-Xylene SCHEMBL18890231 | 0.74 | ACHE (0.92) | ACHEALDH1A1MAPK1TSHRLMNA | |
| Iodide SCHEMBL29488102 | 0.73 | ACHE (0.95) | ACHEAPOBEC3AAPOBEC3GALDH1A1TSHR | |
| Iodide SCHEMBL11797499 | 0.73 | ACHE (0.52) | ACHEAPOBEC3AAPOBEC3GTSHRLMNA | |
| SCHEMBL12339274 | 0.73 | ACHE (0.44) | ACHEALDH1A1MAPK1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9205156-B2 | Molecular imaging agents | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2015-12-08 | — | — | US | disclosed |
| US-20110293519-A1 | MOLECULAR IMAGING AGENTS | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110293519-A1 | MOLECULAR IMAGING AGENTS | TNNI3, FABP3, TNNT2 | ACHE 4083/4885APOBEC3A 3307/4885APOBEC3G 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.