Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.41 |
| ▸ | LPL | P06858 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628655 | 0.79 | POLB (0.65) | POLBHSD17B10KMT2AL3MBTL1PKM | |
| SCHEMBL9985580 | 0.78 | KDM4E (0.49) | POLBHSD17B10KMT2AL3MBTL1TSHR | |
| SCHEMBL9985674 | 0.78 | HTT (0.44) | KMT2AL3MBTL1LMNAMAPTRAB9A | |
| SCHEMBL28326285 | 0.77 | POLB (0.58) | POLBHSD17B10KMT2AL3MBTL1PKM | |
| SCHEMBL9986473 | 0.75 | KMT2A (0.47) | HSD17B10KMT2ALMNAMAPTKDM4E | |
| SCHEMBL9986887 | 0.75 | KEAP1 (0.43) | KMT2ATSHRKDM4EMEN1HIF1A | |
| SCHEMBL15882304 | 0.73 | KMT2A (0.47) | KMT2AL3MBTL1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL257870 | 0.73 | LIPG (0.56) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL20562513 | 0.73 | HIF1A (0.39) | L3MBTL1TSHRLIPGLPLHIF1A | |
| SCHEMBL15143214 | 0.72 | HSD17B10 (0.67) | POLBHSD17B10KMT2AL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | PREP, ADAM10, DNPEP | POLB 3555/4885HSD17B10 1647/4885KMT2A 4143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.