Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 12/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744211 | 0.83 | OGA (0.42) | PTPN11TLR4TLR8OGAKDM4E | |
| SCHEMBL1742764 | 0.82 | OGA (0.46) | HRH3TLR4TLR8OGAKDM4E | |
| SCHEMBL1742772 | 0.82 | OGA (0.44) | PTPN11HRH3TLR4TLR8OGA | |
| SCHEMBL12159783 | 0.82 | FYN (0.46) | PTPN11HRH3TLR4TLR8OGA | |
| SCHEMBL1742868 | 0.81 | SLC6A7 (0.47) | PTPN11HRH3TLR4TLR8KDM4E | |
| SCHEMBL1743089 | 0.79 | CYP1A2 (0.41) | PTPN11HRH3TLR4TLR8OGA | |
| SCHEMBL1742877 | 0.79 | ACACB (0.49) | HRH3OGAKDM4EALDH1A1MAPT | |
| SCHEMBL9987635 | 0.79 | ACHE (0.46) | PTPN11HRH3TLR4TLR8OGA | |
| SCHEMBL1742670 | 0.78 | OGA (0.49) | HRH3OGA | |
| SCHEMBL12159781 | 0.78 | ACHE (0.40) | PTPN11HRH3TLR4TLR8OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-B1 | Histamine H3 receptor antagonists | HIGH POINT PHARMACEUTICALS LLC (US) | 2011-12-07 | — | — | EP | claimed |