Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | OGA | O60502 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743006 | 0.84 | ADAMTS4 (0.43) | ACHEPTPN11OGAHRH3 | |
| SCHEMBL12159781 | 0.84 | ACHE (0.40) | ACHEPTPN11TLR4TLR8OGA | |
| SCHEMBL1743233 | 0.83 | HRH3 (0.42) | ACHEPTPN11ALDH1A1GPR119HRH3 | |
| SCHEMBL1742937 | 0.83 | GPR119 (0.43) | ACHEPTPN11TLR4TLR8OGA | |
| SCHEMBL1742764 | 0.79 | OGA (0.46) | TLR4TLR8OGAHRH3SLC6A7 | |
| SCHEMBL1742772 | 0.79 | OGA (0.44) | PTPN11TLR4TLR8OGAALDH1A1 | |
| SCHEMBL12159783 | 0.79 | FYN (0.46) | ACHEPTPN11TLR4TLR8OGA | |
| SCHEMBL9986179 | 0.79 | PTPN11 (0.39) | ACHEPTPN11TLR4TLR8OGA | |
| SCHEMBL1742868 | 0.78 | SLC6A7 (0.47) | PTPN11TLR4TLR8ALDH1A1GPR119 | |
| SCHEMBL1744211 | 0.77 | OGA (0.42) | ACHEPTPN11TLR4TLR8OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-B1 | Histamine H3 receptor antagonists | HIGH POINT PHARMACEUTICALS LLC (US) | 2011-12-07 | — | — | EP | disclosed |