Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9779087 | 0.84 | PTGER4 (0.46) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL5022814 | 0.83 | PTGER4 (0.43) | ALDH1A1PTGER4MEN1MAPTKMT2A | |
| SCHEMBL6755460 | 0.82 | ALDH1A1 (0.49) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL3057272 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL6753120 | 0.80 | ALDH1A1 (0.46) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL16978834 | 0.79 | ALDH1A1 (0.64) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL15466792 | 0.78 | ALDH1A1 (0.59) | ALDH1A1PTGER4KDM4EMEN1MAPT | |
| SCHEMBL9755646 | 0.78 | GPR3 (0.52) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL30007512 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL9754592 | 0.78 | ALDH1A1 (0.52) | ALDH1A1PTGER4KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |