Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986298 | 1.00 | MAPT (0.38) | MAPTFAAHACHEALDH1A1HTT | |
| SCHEMBL9986502 | 0.88 | GPR119 (0.41) | MAPTALDH1A1HTTMAPK1L3MBTL1 | |
| SCHEMBL9986499 | 0.88 | GPR119 (0.41) | MAPTALDH1A1HTTMAPK1L3MBTL1 | |
| SCHEMBL9986511 | 0.74 | GPR119 (0.43) | MAPTALDH1A1HTTMAPK1L3MBTL1 | |
| SCHEMBL9986508 | 0.74 | GPR119 (0.43) | MAPTALDH1A1HTTMAPK1L3MBTL1 | |
| SCHEMBL11909680 | 0.74 | FAAH (0.44) | MAPTFAAHACHEALDH1A1HTT | |
| SCHEMBL11909682 | 0.74 | FAAH (0.44) | MAPTFAAHACHEALDH1A1HTT | |
| SCHEMBL4749628 | 0.74 | GRK6 (0.42) | MAPTALDH1A1HTTMAPK1DCTPP1 | |
| SCHEMBL4749634 | 0.74 | GRK6 (0.42) | MAPTALDH1A1HTTMAPK1DCTPP1 | |
| SCHEMBL9986228 | 0.72 | HDAC2 (0.53) | MAPTALDH1A1HTTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582681-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | Novartis AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157793-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | NOVARTIS AG (CH) | 2011-12-22 | — | — | WO | disclosed |