Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28745804 | 0.95 | USP2 (0.49) | TSHRUSP2MEN1KMT2APOLB | |
| Propylene Glycol SCHEMBL28166514 | 0.88 | USP2 (0.50) | TSHRUSP2MEN1KMT2AHTT | |
| Alcohol SCHEMBL17821479 | 0.86 | TSHR (0.50) | TSHRUSP2MEN1KMT2APOLB | |
| Propylene Glycol SCHEMBL5675222 | 0.86 | ALDH1A1 (0.47) | USP2ALDH1A1 | |
| Ethylene Glycol SCHEMBL277996 | 0.84 | TSHR (0.54) | TSHRUSP2MEN1KMT2APOLB | |
| SCHEMBL42944 | 0.84 | — | — | |
| Glycerin SCHEMBL1022656 | 0.84 | USP2 (0.58) | TSHRUSP2MEN1KMT2APOLB | |
| 1-Pentanol SCHEMBL28108023 | 0.84 | SMN1; SMN2 (0.43) | TSHRUSP2MEN1KMT2APOLB | |
| Propylene Glycol SCHEMBL8520043 | 0.82 | TDP1 (0.46) | TSHRMEN1KMT2APOLBTDP1 | |
| Propylene Glycol SCHEMBL30304 | 0.82 | TSHR (0.56) | TSHRUSP2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252639-B1 | FOAMED MATERIALS COMPRISING A MATRIX HAVING A HIGH HARDBLOCK CONTENT AND PROCESS FOR PREPARING THEM | HUNTSMAN INT LLC (US) | 2013-05-15 | — | — | EP | disclosed |
| US-8349908-B2 | Foamed materials comprising a matrix having a high highblock content and process for preparing them | HUNTSMAN INTERNATIONAL LLC (US) | 2013-01-08 | — | — | US | disclosed |
| US-20110015287-A1 | FOAMED MATERIALS COMPRISING A MATRIX HAVING A HIGH HIGHBLOCK CONTENT AND PROCESS FOR PREPARING THEM | HUNTSMAN INTERNATIONAL LLC (US) | 2011-01-20 | — | — | US | disclosed |
| EP-2252639-A1 | FOAMED MATERIALS COMPRISING A MATRIX HAVING A HIGH HARDBLOCK CONTENT AND PROCESS FOR PREPARING THEM | Huntsman International LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009109600-A1 | FOAMED MATERIALS COMPRISING A MATRIX HAVING A HIGH HARDBLOCK CONTENT AND PROCESS FOR PREPARING THEM | HUNTSMAN INTERNATIONAL LLC (US) | 2009-09-11 | — | — | WO | disclosed |