Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986884 | 0.90 | KMT2A (0.54) | MAPTTDP1NSD2ALDH1A1ESR1 | |
| SCHEMBL5245757 | 0.83 | L3MBTL1 (0.57) | TDP1MAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL69684 | 0.82 | NSD2 (0.63) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL755296 | 0.82 | SMN1; SMN2 (0.52) | MAPTMAPK1ALDH1A1ESR1ESR2 | |
| SCHEMBL28168705 | 0.81 | NSD2 (0.61) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL8673010 | 0.81 | NSD2 (0.61) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL4357355 | 0.81 | MAPT (0.51) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL10664572 | 0.79 | PARP10 (0.65) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL11215809 | 0.78 | AKR1C3 (0.68) | MAPTTDP1NSD2MAPK1ALDH1A1 | |
| SCHEMBL28519972 | 0.78 | ESR1 (0.73) | MAPTTDP1NSD2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |