Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997784 | 0.90 | KIF11 (0.62) | ABCG2ABCB1MAPTNPSR1LMNA | |
| SCHEMBL9928863 | 0.89 | ABCG2 (0.71) | ABCG2ABCB1MAPTPOLBLMNA | |
| SCHEMBL1000771 | 0.89 | KIF11 (0.67) | ABCG2ABCB1MAPTNPSR1LMNA | |
| SCHEMBL996864 | 0.84 | ABCG2 (0.53) | ABCG2ABCB1MAPTPOLBTP53 | |
| SCHEMBL998179 | 0.82 | TP53 (0.69) | ABCG2ABCB1MAPTNPSR1POLB | |
| SCHEMBL12194947 | 0.81 | PDE5A (0.65) | ABCG2ABCB1MAPT | |
| SCHEMBL998594 | 0.80 | KIF11 (0.59) | ABCG2ABCB1MAPTNPSR1LMNA | |
| SCHEMBL8372051 | 0.79 | LMNA (0.69) | ABCG2ABCB1MAPTNPSR1POLB | |
| SCHEMBL763563 | 0.79 | ABCG2 (0.74) | ABCG2ABCB1MAPTPOLBLMNA | |
| SCHEMBL8402610 | 0.78 | KIF11 (0.72) | ABCG2ABCB1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20060154944-A1 | Novel tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-13 | — | — | US | disclosed |
| EP-1637521-A1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154944-A1 | Novel tricyclic heterocycle compound | CYP11B1, CYP11B2, HCCS | ABCG2 309/4885ABCB1 307/4885MAPT 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.