Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807403 | 1.00 | GPBAR1 (0.46) | GPBAR1CYSLTR1GAAHSD17B10MTNR1A | |
| SCHEMBL11665507 | 0.86 | GPBAR1 (0.55) | GPBAR1CYSLTR1GAAHSD17B10MTNR1A | |
| SCHEMBL2092088 | 0.81 | GPBAR1 (0.48) | GPBAR1CYSLTR1GAAHSD17B10MTNR1A | |
| SCHEMBL1808381 | 0.80 | RXRA (0.50) | GAAALDH1A1 | |
| SCHEMBL13790939 | 0.79 | ACHE (0.50) | GPBAR1CYSLTR1GAAHSD17B10ALDH1A1 | |
| SCHEMBL13791121 | 0.79 | ACHE (0.50) | GPBAR1CYSLTR1GAAHSD17B10ALDH1A1 | |
| SCHEMBL13791767 | 0.79 | MTNR1A (0.59) | GPBAR1CYSLTR1MTNR1AMTNR1BTSHR | |
| SCHEMBL13791679 | 0.79 | MTNR1A (0.59) | GPBAR1CYSLTR1MTNR1AMTNR1BTSHR | |
| SCHEMBL27666317 | 0.79 | GAA (0.44) | GPBAR1CYSLTR1GAAHSD17B10MTNR1A | |
| SCHEMBL3173884 | 0.78 | CYP3A4 (0.50) | GPBAR1CYSLTR1GAAHSD17B10MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |