Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL28079833 | 0.93 | GCK (0.56) | GCKHTTTDP1L3MBTL1RORC | |
| SCHEMBL8941513 | 0.88 | HTT (0.57) | GCKHTTTDP1L3MBTL1RORC | |
| SCHEMBL12070248 | 0.82 | GCK (0.60) | GCK | |
| SCHEMBL12897604 | 0.82 | GCK (0.50) | GCKHTTCA2 | |
| SCHEMBL10329791 | 0.81 | GCK (0.60) | GCK | |
| SCHEMBL1107736 | 0.81 | GCK (0.60) | GCKPTGS2 | |
| SCHEMBL9034923 | 0.81 | PTGS2 (0.55) | GCKPTGS2 | |
| SCHEMBL2666561 | 0.80 | GCK (0.59) | GCK | |
| SCHEMBL28079831 | 0.80 | GCK (0.57) | GCKPTGS2 | |
| SCHEMBL3600059 | 0.80 | GCK (0.60) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |