Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 8/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998730 | 1.00 | MAPT (0.59) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL997110 | 0.99 | MAPT (0.60) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL997108 | 0.99 | MAPT (0.60) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL998259 | 0.92 | KEAP1 (0.59) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL998257 | 0.92 | KEAP1 (0.59) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL996162 | 0.90 | MAOB (0.56) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL996164 | 0.90 | MAOB (0.56) | MAPTKDM4EMEN1NPC1GAA | |
| SCHEMBL997479 | 0.89 | MAOB (0.56) | MAPTNPC1RAB9AMAOBDRD2 | |
| SCHEMBL997477 | 0.89 | MAOB (0.56) | MAPTNPC1RAB9AMAOBDRD2 | |
| SCHEMBL998221 | 0.88 | HIF1AN (0.54) | MAPTMAOBCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | claimed |
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |