Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987406 | 0.84 | GCK (0.56) | GCKLRRK2KDM4ECCNT1CDK9 | |
| SCHEMBL9987668 | 0.75 | RORC (0.46) | KDM4E | |
| SCHEMBL9987616 | 0.73 | KDM4E (0.37) | LRRK2KDM4E | |
| SCHEMBL9986987 | 0.72 | GCK (1.00) | GCK | |
| SCHEMBL9986894 | 0.72 | KDM4E (0.47) | KDM4E | |
| SCHEMBL9987614 | 0.72 | KDM4E (0.38) | KDM4E | |
| SCHEMBL9986303 | 0.69 | GCK (0.82) | GCK | |
| SCHEMBL9987956 | 0.68 | GCK (1.00) | GCK | |
| SCHEMBL1140554 | 0.67 | KDM4E (0.48) | KDM4E | |
| SCHEMBL9986870 | 0.67 | GCK (0.73) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | claimed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |