Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.46 |
| ▸ | RORA | P35398 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986894 | 0.83 | KDM4E (0.47) | RORCKDM4EHRH3CYP2D6MEN1 | |
| SCHEMBL1140554 | 0.78 | KDM4E (0.48) | RORCRORAKDM4EHRH3CYP2D6 | |
| SCHEMBL1107306 | 0.77 | KDM4E (0.47) | RORCRORAKDM4EHRH3CYP2D6 | |
| SCHEMBL9987288 | 0.75 | GCK (0.56) | KDM4E | |
| SCHEMBL9987614 | 0.74 | KDM4E (0.38) | RORCKDM4EHRH3FPR2PROKR1 | |
| SCHEMBL9987406 | 0.74 | GCK (0.56) | RORCKDM4ECACNB4CACNA1ACACNA1G | |
| SCHEMBL9987616 | 0.73 | KDM4E (0.37) | RORCKDM4EHRH3FPR2PROKR1 | |
| SCHEMBL15428503 | 0.71 | HRH3 (0.43) | RORCHRH3FPR2PROKR1CYP2D6 | |
| SCHEMBL15263145 | 0.71 | HRH3 (0.43) | RORCHRH3FPR2PROKR1CYP2D6 | |
| SCHEMBL18672933 | 0.71 | RORC (0.53) | RORCRORAHRH3FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |