Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422979 | 0.87 | GCK (0.51) | GCK | |
| SCHEMBL423250 | 0.83 | CA1 (0.43) | GCKCA1CA2CA9PTGS2 | |
| SCHEMBL9987674 | 0.83 | GCK (0.39) | GCKCA1CA2CA9PTGS2 | |
| SCHEMBL12070248 | 0.77 | GCK (0.60) | GCKMMP2MMP3MMP9MMP14 | |
| SCHEMBL3600059 | 0.75 | GCK (0.60) | GCK | |
| SCHEMBL28079831 | 0.75 | GCK (0.57) | GCKPTGS2MMP2MMP3MMP9 | |
| SCHEMBL9987330 | 0.74 | MEN1 (0.42) | CA1CA2CA9MMP2MMP3 | |
| SCHEMBL24270024 | 0.74 | CA1 (0.38) | GCKCA1CA2CA9 | |
| SCHEMBL9987196 | 0.74 | GCK (0.62) | GCKCA2PTGS2 | |
| SCHEMBL10329791 | 0.74 | GCK (0.60) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |