Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987396 | 0.83 | GCK (0.51) | GCKCA1CA2CA9PTGS2 | |
| SCHEMBL2656722 | 0.76 | GCK (0.47) | GCKPTGS2 | |
| SCHEMBL9987882 | 0.74 | GCK (0.47) | GCKPTGS2PTGS1 | |
| SCHEMBL2659524 | 0.74 | GCK (0.45) | GCKCA1CA2CA9PTGS2 | |
| SCHEMBL422979 | 0.73 | GCK (0.51) | GCK | |
| SCHEMBL423250 | 0.73 | CA1 (0.43) | GCKCA1CA2CA9PTGS2 | |
| SCHEMBL25408676 | 0.71 | PTGS1 (0.33) | PTGS2PTGS1 | |
| SCHEMBL16496761 | 0.70 | CA1 (0.43) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL10904 | 0.70 | CA1 (0.56) | CA1CA2CA9CA12CA3 | |
| SCHEMBL2667759 | 0.69 | GCK (0.47) | GCKPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |